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KMID : 1149120210180020039
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Journal of the Korean Society for Psoriasis
2021 Volume.18 No. 2 p.39 ~ p.42
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Laryngeal Cancer in a Patient with Psoriasis Treated with Guselkumab: A Case Report
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Choi Go-Woon
Kim Dong-Hyun
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Abstract
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Although biologics are highly effective in psoriasis, they have significant effects on innate and adaptive immune systems that may negatively impact on mechanisms of cancer immunosurveillance. However, there are limited data on the risk of cancer in psoriasis patients treated with biologics. A 70 years-old male patient presented with plaque psoriasis for four years’ duration. After receiving methotrexate for nine months, guselkumab was started due to inefficacy. After two years of guselkumab therapy, he visited the otolaryngologist with the voice change and pain around the left jaw for one year. The result of laryngoscopic biopsy showed a left supraglottic squamous cell carcinoma, and there was no metastasis on additional imaging studies. He was transferred to another hospital for surgery and concurrent chemoradiation therapy, and continues guselkumab treatment. Herein, we report on a case of laryngeal cancer during guselkumab treatment in a patient with psoriasis with the review of literatures.
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KEYWORD
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Guselkumab, Interleukin-23, Laryngeal neoplasms, Psoriasis
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